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        <Text language="fre">&lt;p&gt;Le dopage du cheval de sport est une pratique tr&amp;egrave;s ancienne, potentiellement nocive pour la sant&amp;eacute; de l&amp;#39;animal. Son d&amp;eacute;pistage fait appel &amp;agrave; des techniques analytiques performantes permettant de rechercher dans des pr&amp;eacute;l&amp;egrave;vements biologiques de nombreuses substances de pharmacocin&amp;eacute;tique variable. Cet ouvrage pr&amp;eacute;sente de mani&amp;egrave;re synth&amp;eacute;tique et accessible aux non-sp&amp;eacute;cialistes les aspects scientifiques et r&amp;eacute;glementaires de ce sujet toujours plein d&amp;#39;actualit&amp;eacute;.&lt;/p&gt;</Text>
        <Text language="eng">&lt;p&gt;Doping racehorses is an age-old practice potentially noxious to the health of the animal. Screening uses high-performance analysis techniques to detect a number of substances with variable pharmacokinetic properties in the biological samples. The succinct style makes the scientific and legal aspects of this topical question accessible to non-specialists.&lt;/p&gt;</Text>
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        <Text>Le dopage du cheval de sport est une pratique très ancienne, potentiellement nocive pour la santé de l'animal. Son dépistage fait appel à des techniques analytiques performantes permettant de rechercher dans des prélèvements biologiques de nombreuses substances de pharmacocinétique variable. Cet ouvrage présente de manière synthétique et accessible aux non-spécialistes les aspects scientifiques et réglementaires de ce sujet toujours plein d'actualité.</Text>
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        <Text>&lt;p&gt;&lt;br /&gt;Chapitre 1. &amp;mdash; Rappels pharmaco&amp;ccedil;in&amp;eacute;tiques et toxicologiques&lt;br /&gt;I. Rappels pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;1. Passage des m&amp;eacute;dicaments &amp;agrave; travers les membranes&lt;br /&gt;2. Phases pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;2.1. Absorption&lt;br /&gt;2.2. Distribution&lt;br /&gt;2.3. Biotransformations&lt;br /&gt;2.4. Elimination&lt;br /&gt;3. Les mod&amp;egrave;les et les param&amp;egrave;tres pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;II. Applications des donn&amp;eacute;es cin&amp;eacute;tiques au contr&amp;ocirc;le antidopage&lt;br /&gt;1. Les pr&amp;eacute;l&amp;egrave;vements&lt;br /&gt;1.1. Salive&lt;br /&gt;1.2. Sang&lt;br /&gt;1.3. Urine&lt;br /&gt;2. Influence des variations du devenir du m&amp;eacute;dicament sur les r&amp;eacute;sultats du contr&amp;ocirc;le antidopage&lt;br /&gt;2.1. Absorption&lt;br /&gt;2.2. Biotransformations&lt;br /&gt;2.3. Elimination&lt;br /&gt;III. Effets nocifs des agents dopants&lt;br /&gt;1. Anabolisants&lt;br /&gt;1.1. Effets hormonaux&lt;br /&gt;1.2. Effets sur la croissance et l&amp;#39;ossification&lt;br /&gt;2. Tranquillisants&lt;br /&gt;3. Anti-inflammatoires non st&amp;eacute;ro&amp;iuml;diens&lt;br /&gt;Chapitre 2. &amp;mdash; Aspects analytiques&lt;br /&gt;I. Le criblage&lt;br /&gt;1. Extraction et purification&lt;br /&gt;2. Identification&lt;br /&gt;2.1. Chromatographie en phase gazeuse&lt;br /&gt;2.2. Chromatographie liquide haute performance&lt;br /&gt;IL La confirmation&lt;br /&gt;1. Principe de la spectrom&amp;eacute;trie de masse (SM)&lt;br /&gt;2. Le couplage chromatographie en phase gazeuse - spectrom&amp;eacute;trie de masse&lt;br /&gt;2.1. Qualit&amp;eacute;s&lt;br /&gt;2.2. Modalit&amp;eacute;s d&amp;#39;emploi&lt;br /&gt;2.3. Appareillage&lt;br /&gt;III. R&amp;eacute;sultats et interpr&amp;eacute;tations&lt;br /&gt;1. Obtention des r&amp;eacute;sultats&lt;br /&gt;2. Les &amp;laquo; substances interf&amp;eacute;rentes &amp;raquo;&lt;br /&gt;2.1. Substances artificielles&lt;br /&gt;2.2. Substances naturelles&lt;br /&gt;Chapitre 3. &amp;mdash; Les agents dopants&lt;br /&gt;I. Neuroleptiques et tranquillisants&lt;br /&gt;II. B&amp;ecirc;tabloquants et cardiotoniques&lt;br /&gt;III. Neurostimulants et analeptiques cardiovasculaires&lt;br /&gt;IV. Morphiniques&lt;br /&gt;V. Anti-inflammatoires non st&amp;eacute;ro&amp;iuml;diens&lt;br /&gt;VI. Glucocortico&amp;iuml;des&lt;br /&gt;VIL Diur&amp;eacute;tiques&lt;br /&gt;VIII. Anesth&amp;eacute;siques locaux&lt;br /&gt;IX. Anesth&amp;eacute;siques g&amp;eacute;n&amp;eacute;raux&lt;br /&gt;X. M&amp;eacute;dicaments divers&lt;br /&gt;Chapitre 4. &amp;mdash; Aspects r&amp;eacute;glementaires&lt;br /&gt;I. Contr&amp;ocirc;le quantitatif et contr&amp;ocirc;le qualitatif&lt;br /&gt;1. R&amp;eacute;glementation restrictive&lt;br /&gt;2. R&amp;eacute;glementation reposant sur une m&amp;eacute;dication contr&amp;ocirc;l&amp;eacute;e&lt;br /&gt;IL Textes r&amp;eacute;glementaires&lt;br /&gt;1. D&amp;eacute;cret n&amp;deg; 87-473 du 1e r juillet 1987&lt;br /&gt;2. Loi n&amp;deg; 89-432 du 28 juin 1989&lt;br /&gt;&amp;nbsp;&lt;/p&gt;</Text>
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        <Text language="fre">&lt;p&gt;Le dopage du cheval de sport est une pratique tr&amp;egrave;s ancienne, potentiellement nocive pour la sant&amp;eacute; de l&amp;#39;animal. Son d&amp;eacute;pistage fait appel &amp;agrave; des techniques analytiques performantes permettant de rechercher dans des pr&amp;eacute;l&amp;egrave;vements biologiques de nombreuses substances de pharmacocin&amp;eacute;tique variable. Cet ouvrage pr&amp;eacute;sente de mani&amp;egrave;re synth&amp;eacute;tique et accessible aux non-sp&amp;eacute;cialistes les aspects scientifiques et r&amp;eacute;glementaires de ce sujet toujours plein d&amp;#39;actualit&amp;eacute;.&lt;/p&gt;</Text>
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        <Text language="fre">&lt;p&gt;Le dopage du cheval de sport est une pratique tr&amp;egrave;s ancienne, potentiellement nocive pour la sant&amp;eacute; de l&amp;#39;animal. Son d&amp;eacute;pistage fait appel &amp;agrave; des techniques analytiques performantes permettant de rechercher dans des pr&amp;eacute;l&amp;egrave;vements biologiques de nombreuses substances de pharmacocin&amp;eacute;tique variable. Cet ouvrage pr&amp;eacute;sente de mani&amp;egrave;re synth&amp;eacute;tique et accessible aux non-sp&amp;eacute;cialistes les aspects scientifiques et r&amp;eacute;glementaires de ce sujet toujours plein d&amp;#39;actualit&amp;eacute;.&lt;/p&gt;</Text>
        <Text language="eng">&lt;p&gt;Doping racehorses is an age-old practice potentially noxious to the health of the animal. Screening uses high-performance analysis techniques to detect a number of substances with variable pharmacokinetic properties in the biological samples. The succinct style makes the scientific and legal aspects of this topical question accessible to non-specialists.&lt;/p&gt;</Text>
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        <Text>Le dopage du cheval de sport est une pratique très ancienne, potentiellement nocive pour la santé de l'animal. Son dépistage fait appel à des techniques analytiques performantes permettant de rechercher dans des prélèvements biologiques de nombreuses substances de pharmacocinétique variable. Cet ouvrage présente de manière synthétique et accessible aux non-spécialistes les aspects scientifiques et réglementaires de ce sujet toujours plein d'actualité.</Text>
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        <Text>&lt;p&gt;&lt;br /&gt;Chapitre 1. &amp;mdash; Rappels pharmaco&amp;ccedil;in&amp;eacute;tiques et toxicologiques&lt;br /&gt;I. Rappels pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;1. Passage des m&amp;eacute;dicaments &amp;agrave; travers les membranes&lt;br /&gt;2. Phases pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;2.1. Absorption&lt;br /&gt;2.2. Distribution&lt;br /&gt;2.3. Biotransformations&lt;br /&gt;2.4. Elimination&lt;br /&gt;3. Les mod&amp;egrave;les et les param&amp;egrave;tres pharmaco&amp;ccedil;in&amp;eacute;tiques&lt;br /&gt;II. Applications des donn&amp;eacute;es cin&amp;eacute;tiques au contr&amp;ocirc;le antidopage&lt;br /&gt;1. Les pr&amp;eacute;l&amp;egrave;vements&lt;br /&gt;1.1. Salive&lt;br /&gt;1.2. Sang&lt;br /&gt;1.3. Urine&lt;br /&gt;2. Influence des variations du devenir du m&amp;eacute;dicament sur les r&amp;eacute;sultats du contr&amp;ocirc;le antidopage&lt;br /&gt;2.1. Absorption&lt;br /&gt;2.2. Biotransformations&lt;br /&gt;2.3. Elimination&lt;br /&gt;III. Effets nocifs des agents dopants&lt;br /&gt;1. Anabolisants&lt;br /&gt;1.1. Effets hormonaux&lt;br /&gt;1.2. Effets sur la croissance et l&amp;#39;ossification&lt;br /&gt;2. Tranquillisants&lt;br /&gt;3. Anti-inflammatoires non st&amp;eacute;ro&amp;iuml;diens&lt;br /&gt;Chapitre 2. &amp;mdash; Aspects analytiques&lt;br /&gt;I. Le criblage&lt;br /&gt;1. Extraction et purification&lt;br /&gt;2. Identification&lt;br /&gt;2.1. Chromatographie en phase gazeuse&lt;br /&gt;2.2. Chromatographie liquide haute performance&lt;br /&gt;IL La confirmation&lt;br /&gt;1. Principe de la spectrom&amp;eacute;trie de masse (SM)&lt;br /&gt;2. Le couplage chromatographie en phase gazeuse - spectrom&amp;eacute;trie de masse&lt;br /&gt;2.1. Qualit&amp;eacute;s&lt;br /&gt;2.2. Modalit&amp;eacute;s d&amp;#39;emploi&lt;br /&gt;2.3. Appareillage&lt;br /&gt;III. R&amp;eacute;sultats et interpr&amp;eacute;tations&lt;br /&gt;1. Obtention des r&amp;eacute;sultats&lt;br /&gt;2. Les &amp;laquo; substances interf&amp;eacute;rentes &amp;raquo;&lt;br /&gt;2.1. Substances artificielles&lt;br /&gt;2.2. Substances naturelles&lt;br /&gt;Chapitre 3. &amp;mdash; Les agents dopants&lt;br /&gt;I. Neuroleptiques et tranquillisants&lt;br /&gt;II. B&amp;ecirc;tabloquants et cardiotoniques&lt;br /&gt;III. Neurostimulants et analeptiques cardiovasculaires&lt;br /&gt;IV. Morphiniques&lt;br /&gt;V. Anti-inflammatoires non st&amp;eacute;ro&amp;iuml;diens&lt;br /&gt;VI. Glucocortico&amp;iuml;des&lt;br /&gt;VIL Diur&amp;eacute;tiques&lt;br /&gt;VIII. Anesth&amp;eacute;siques locaux&lt;br /&gt;IX. Anesth&amp;eacute;siques g&amp;eacute;n&amp;eacute;raux&lt;br /&gt;X. M&amp;eacute;dicaments divers&lt;br /&gt;Chapitre 4. &amp;mdash; Aspects r&amp;eacute;glementaires&lt;br /&gt;I. Contr&amp;ocirc;le quantitatif et contr&amp;ocirc;le qualitatif&lt;br /&gt;1. R&amp;eacute;glementation restrictive&lt;br /&gt;2. R&amp;eacute;glementation reposant sur une m&amp;eacute;dication contr&amp;ocirc;l&amp;eacute;e&lt;br /&gt;IL Textes r&amp;eacute;glementaires&lt;br /&gt;1. D&amp;eacute;cret n&amp;deg; 87-473 du 1e r juillet 1987&lt;br /&gt;2. Loi n&amp;deg; 89-432 du 28 juin 1989&lt;br /&gt;&amp;nbsp;&lt;/p&gt;</Text>
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