Epigenetics

Acknowledgements

Introduction

Hélène Jammes, Pierre Boudry, Stéphane Maury

Chapter 1: Epigenetics, a word in the history of science

Gaëlle Pontarotti

Epigenetics, a word with a history

Epigenetics, a cross-cutting issue in biology

Epigenetics, a concept with multiple epistemological and social implications

Conclusion

References

Chapter 2. Epigenetics, an exploration of molecular processes

Hélène Jammes, David L'Hôte

Genetic heritage in all its states

The "histone code”

DNA methylation, the most extensively explored epigenetic mark

Activities of long and small non-coding RNAs in epigenetic regulation

Polycomb and Trithorax proteins

Conclusion

References

Chapter 3. X chromosome inactivation

Clara Roidor, Véronique Duranthon, Maud Borensztein

Gene dose compensation

Discovery of X chromosome inactivation

The power of mouse models

The X chromosome inactivation cycle in rodents: a model apart?

Diversity of the X chromosome inactivation process in eutherians

Benefits and pathologies associated with X chromosome inactivation

Conclusion and outlook

References

Chapter 4: Parental genomic imprinting: discovery and regulatory mechanisms

Thierry Forné

Evolution and parental genomic imprinting

Molecular origin of genomic imprinting mechanisms

Epigenetic control of imprinted genes

Imprinting centers and the parental genomic imprinting cycle

Examples of molecular mechanisms of functional imprinting

Conclusion

References

Chapter 5: Parental genomic imprinting in farm animals

Julie Demars, Catherine Labbé, Frédérique Pitel

Parental genomic imprinting and phenotypic variability

Characterization of imprinting mechanisms in farm animals

Potential implications for breeding

References

Chapter 6. Parental imprinting in plants: mechanisms, functions and applications

Clément Lafon Placette

Overview of sexual reproduction in plants

Epigenetic mechanisms leading to parental imprinting

Death of the hybrid seed: parental imprinting, the usual suspect

Evolutionary causes of parental imprinting in plants

Application to plant breeding

References

Chapter 7. Life in utero: epigenetic programming of traits

Anne Gabory

The developmental origins of disease

Epigenetics and DOHaD

Epigenetics and gender variation in response

Conclusion: the developmental origins of health

References

Chapter 8. Epigenetic clock

Sarah Voisin

Show me your epigenome, and I'll tell you your age

An epigenetic clock is not rocket science!

Biological age versus chronological age

Can you have an old liver and a young muscle at the same time?

No animal species escapes epigenetic ageing

Aging is accompanied by erosion of the methylome

Conclusion

References

Chapter 9. Epigenetic mechanisms of host-pathogen interactions

Christoph Grunau, Isabelle Fudal, Nadia Ponts

Epigenome modification following pathogen infection

Epigenetic memory and priming of plant defenses during infection

Role of DNA methylation in the induction of defense responses in plants

Future questions

References

Chapter 10. Epigenetic memories and plant health

Philippe Gallusci, Margot M.J. Berger

Plant memory: the importance of epigenetic mechanisms

Plant acclimatization: somatic memory and plant health

Inter-transgenerational epigenetic memory of stress: consequences for plant health

Epigenetic diversity and crop improvement

Conclusion

References

Chapter 11. Epigenetics in farmed fish

Audrey Laurent, Delphine Lallias, Lucie Marandel, Catherine Labbé, Pierre Boudry

Complex duplicated genomes at the origin of new epigenetic regulators

Originality of methylome genetic support in teleosts

Epigenetic mechanisms and modulation of intragenerational physiological responses

Intergenerational transmission of environmental information

Conclusion

References

Chapter 12. Epigenome editing

David L'Hôte

Epigenome editing tools

Epigenome editing in the service of health

Conclusion

References

Conclusion

List of authors